Recent Publications

Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I.
Hossain MA, Ngeth S, Chan T, Oda MN, Francis GA.
BMC Biochem. 2012 Jan 16;13(1):1. [Epub ahead of print]

Mechanical properties of asthmatic airway smooth muscle.
Chin LY, Bosse Y, Pascoe C, Hackett TL, Seow CY, Pare PD.
Eur Respir J. 2012 Jan 20. [Epub ahead of print]

Force oscillations simulating breathing maneuvers do not prevent force adaptation.
Pascoe C, Jiao Y, Seow CY, Pare PD, Bosse Y.
American Journal of Respiratory Cell and Molecular Biology.

Cost-effective prediction of gender-labeling errors and estimation of gender-labeling error rates in candidate-gene association studies.
Qu C, Schuetz JM, Min JE, Leach S, Daley D, Spinelli JJ, Brooks-Wilson A, Graham J.
Front Genet. 2011;2:31. PMID: 22303327 [PubMed - in process]

Mapping of the Wnt/β-Catenin/TCF Response Elements in the Human Versican Promoter.
Rahmani M, Carthy JM, McManus BM. 
Methods Mol Biol. 2012;836:35-52. PMID: 22252626

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.
Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA.
J Allergy Clin Immunol. 2012 Jan 7.

Inflammation in myocardial diseases.
Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM.
Circ Res. 2012 Jan 6;110(1):126-44. PMID: 22223210

Induction of Endothelial Nitric Oxide Synthase Expression by IL-17 in Human Vascular Endothelial Cells: Implications for Vascular Remodeling in Transplant Vasculopathy.
Liu AC, Lee M, McManus BM, Choy JC.
J Immunol. 2012 Jan 4. PMID: 22219320

Immune and non-immune functions of the immunoproteasome.
Angeles A, Fung G, Luo H.
Front Biosci. 2012 Jan 1;17:1904-16.

Genetic association between human chitinases and lung function in COPD.
Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ.
Hum Genet. 2011 Dec 28.

ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.
Boadu E, Nelson RC, Francis GA.
Biochim Biophys Acta. 2011 Dec 10. [Epub ahead of print]

Neutrophil-Mediated Lung Damage: A New COPD Phenotype?
Sin D, van Eeden SF.
Respiration. 2011 Dec 6. PMID: 22142967

Genetic association between human chitinases and lung function in COPD.
Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ.
Hum Genet. 2011 Dec 2

2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology.
Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d’Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL.
Cardiovasc Pathol. 2011 Dec 1. PMID: 22137237

Occupational exposure influences on gender differences in respiratory health.
Dimich-Ward H, Beking K, Dybuncio A, Chan-Yeung M, Du W, Karlen B, Camp PG, Kennedy SM.
Lung 2011 Nov 15.

The immunity-related gtpase irgm3 relieves endoplasmic reticulum stress response during coxsackievirus b3 infection via a pi3k/akt dependent pathway.
Liu Z, Zhang HM, Yuan J, Ye X, Taylor GA, Yang DC.
Cell Microbiol 2011.

WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication.
Carthy JM, Luo Z, McManus BM
Lab Invest. 2011 Nov 21. PMID: 22105568

Inotropes and vasopressors: more than hemodynamics!
Bracht H, Calzia E, Georgieff M, Singer J, Radermacher P, Russell JA.
Br J Pharmacol. 2011 Nov 10. doi: 10.1111/j.1476-5381.2011.01776.x.

The protective role of tlr6 in a mouse model of asthma is mediated by il-23 and il-17a.
Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM.
J Clin Invest 2011 Nov 1;121(11):4420-32. doi: 10.1172/JCI44999.

The Semantic Automated Discovery and Integration (SADI) Web service Design-Pattern, API and Reference Implementation.
Wilkinson MD, Vandervalk B, McCarthy L.
J Biomed Semantics. 2011 Oct 24;2(1):8.

IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis.
Nakada TA, Russell JA, Boyd JH, Walley KR.
Crit Care. 2011 Oct 25;15(5):R254.

Regulatable stiffness in relaxed airway smooth muscle: A target for asthma treatment?
Raqeeb A, Jiao Y, Syyong HT, Pare PD, Seow CY.
J Appl Physiol. 2011 Oct 13.

Targeting endothelial dysfunction in vascular complications associated with diabetes.
Sharma A, Bernatchez PN, de Haan JB.
Int J Vasc Med 2012;2012:750126.

Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.
Kerkhof M, Daley D, Postma DS, Park JE, Chan Yeung M, Wijga AH, Gehring U, de Jongste JC, Smit HA, Brunekreef B, van Schayck OC, Becker A, Koppelman GH.
J Allergy Clin Immunol. 2011 Oct 12.

Incidence of pancreatitis, secondary causes, and treatment of patients referred to a specialty lipid clinic with severe hypertriglyceridemia: a retrospective cohort study.
Sandhu S, Al-Sarraf A, Taraboanta C, Frohlich J, Francis GA.
Lipids Health Dis 2011;10:157 (1-7).

Molecular signatures of end-stage heart failure.
Lin D, Hollander Z, Meredith A, Stadnick E, Sasaki M, Cohen Freue G, Qasimi P, Mui A, Ng RT, Balshaw R, Wilson-McManus JE, Wishart D, Hau D, Keown PA, McMaster R, McManus BM.
J Card Fail. 2011 Oct;17(10):867-74.

Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 and Formation of High Density Lipoproteins in Cholesterol Ester Storage Disease.
Kristin L. Bowden, Nicolas J. Bilbey, Leanne M. Bilawchuk, Emmanuel Boadu, Rohini Sidhu, Daniel S. Ory, Hong Du, Teddy Chan, and Gordon A. Francis.
J Biol Chem 2011;286:30624-35.

Smoking kills, quitting heals: the importance of smoking cessation in COPD.
Park HY, Sin D.
Clin Respir J. 2011 Oct;5(4):185-6. doi: 10.1111/j.1752-699X.2011.00270.x.

Confirmed Swine-Origin Influenza A(H1N1) Viral Pneumonia: Computed Tomographic Findings in the Immunocompetent and the Immunocompromised.
Chandler TM, Leipsic J, Nicolaou S, Quiney B, Romney M, Müller NL, Ajlan AM.
J Comput Assist Tomogr. 2011 Sep-Oct;35(5):602-7.

Changes in forced expiratory volume in 1 second over time in COPD.
Vestbo J, Edwards LD, Scanlon PD, Yates JC, Agusti A, Bakke P, Calverley PM, Celli B, Coxson HO, Crim C, Lomas DA, MacNee W, Miller BE, Silverman EK, Tal-Singer R, Wouters E, Rennard SI; ECLIPSE Investigators.
N Engl J Med. 2011 Sep 29;365(13):1184-92. Epub 2011 Sep 26.

A Successful 4S Heart Transplantation.
Al-Mohaissen MA, Ignaszewski AP, Cheung A, Kaan A, Chiu W, Kealy J, Virani SA.
Can J Cardiol. 2011 Sep 21.

The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter.
Miyata R, van Eeden SF.
Toxicol Appl Pharmacol. 2011 Sep 17.

Gender differences in symptoms of myocardial ischaemia.
Mackay MH, Ratner PA, Johnson JL, Humphries KH, Buller CE.
Eur Heart J. 2011 Sep 14.

A ‘Good’ muscle in a ‘Bad’ environment: The importance of airway smooth muscle force adaptation to airway hyperresponsiveness.
Bosse Y, Chapman DG, Pare PD, King GG, Salome CM.
Respir Physiol Neurobiol. 2011 Sep 14

Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm.
Ang LS, Boivin WA, Williams SJ, Zhao H, Abraham T, Carmine-Simmen K, McManus BM, Bleackley RC, Granville DJ.
Cell Death Dis. 2011 Sep 8;2:e209. doi: 10.1038/cddis.2011.88.

Diagnostic performance of high-definition coronary computed tomography angiography performed with multiple radiation dose reduction strategies.
Heydari B, Leipsic J, Mancini GB, Min JK, Labounty T, Taylor C, Freue GV, Heilbron B.
Can J Cardiol. 2011 Sep;27(5):606-12.

Effect of gene environment interactions on lung function and cardiovascular disease in COPD.
Hackett TL, Stefanowicz D, Aminuddin F, Sin DD, Connett JE, Anthonisen NR, Paré PD, Sandford AJ.
Int J Chron Obstruct Pulmon Dis. 2011;6:277-87. Epub 2011 May 10.

The TLR9 ligand CpG-C attenuates acute inflammatory cardiac dysfunction.
Mathur S, Walley KR, Boyd JH.
Shock. 2011 Sep 7.

Defective function at the epithelial junction: A novel therapeutic frontier in asthma?
Knight DA, Stick SM, Hackett TL.
J Allergy Clin Immunol. 2011 Sep;128(3):557-8.

Is Atherosclerotic Heart Disease in COPD a Distinct Phenotype?
Man SF, Leipsic JA, Man JP, Sin DD.
Chest. 2011 Sep;140(3):569-71.

Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus.
Oosthuizen JL, Gomez P, Ruan J, Hackett TL, Moore MM, Knight DA, Tebbutt SJ.
PLoS One. 2011;6(5):e20527. Epub 2011 May 31.

Vascular endothelial growth factor-D is overexpressed in human cardiac allograft vasculopathy and diabetic atherosclerosis and induces endothelial permeability to low-density lipoproteins in vitro.
Wong BW, Wong D, Luo H, McManus BM.
J Heart Lung Transplant. 2011 Aug;30(8):955-62. Epub 2011 May 28.

Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner.
Carthy JM, Garmaroudi FS, Luo Z, McManus BM.
PLoS One. 2011;6(5):e19809. Epub 2011 May 18.

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.
Tayyari F, Marchant D, Moraes TJ, Duan W, Mastrangelo P, Hegele RG.
Nat Med. 2011 Aug 14;17(9):1132-5. doi: 10.1038/nm.2444.

Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice.
Hiebert PR, Boivin WA, Abraham T, Pazooki S, Zhao H, Granville DJ.
Exp Gerontol. 2011 Jun;46(6):489-99. Epub 2011 Feb 18.